Mind the IQGAP

The biology of IQGAP proteins: beyond the cytoskeleton.

IQGAP scaffold proteins are evolutionarily conserved in eukaryotes and facilitate the formation of complexes that regulate cytoskeletal dynamics, intracellular signaling, and intercellular interactions. Fungal and mammalian IQGAPs are implicated in cytokinesis. IQGAP1, IQGAP2, and IQGAP3 have diverse roles in vertebrate physiology, operating in the kidney, nervous system, cardio-vascular system...

Author ' s response to reviews Title : IQGAP 1 and IQGAP 2 are Reciprocally Altered in Hepatocellular

Microtubule Capture: IQGAP and CLIP-170 Expand the Repertoire

Rho GTPases regulate microtubule capture near the cell cortex to polarize cells. What is surprising is the repertoire of interactions between proteins at the ends of microtubules and their cortical targets. The microtubule tip protein CLIP-170 has now been found to interact with the Cdc42/Rac effector IQGAP and mediate transient capture of microtubules.

IQGAP Family Members in Yeast, Dictyostelium, and Mammalian Cells

IQGAPs are a family of scaffolding proteins with multiple domains, named for the IQ motifs and GTPase activating protein (GAP) related domains. Despite their GAP homology, IQGAP proteins act as effectors for GTP-bound GTPases of the Ras superfamily and do not stimulate GTP hydrolysis. IQGAPs are found in eukaryotic cells from yeast to human, and localize to actin-containing structures such as l...

The Triune Brain: Limbic Mind Mind Plastic, Emotional Mind

Problem statement: The theory discussed is revealing, as compared to studies on the human brain, the fact that he has inherited the structure and organization of three fundamental types of reptiles, ancient or primitive mammals and mammals, or recent evolved. What is very disconcerting is that nature has been able to connect with each other and establish a sort of communication between them. Ap...